Mesothelioma Surgery

Specialists have developed various surgical procedures to help treat pleural, peritoneal, and pericardial mesothelioma. Surgery is the most effective treatment for extending patient survival, especially when combined with chemotherapy and radiation.

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How Mesothelioma Surgery Impacts Life Expectancy

Surgery is the best option for mesothelioma patients to live longer. There are life-extending procedures for both pleural and peritoneal mesothelioma.

Many more pleural mesothelioma patients are living past the 3-year mark. Early-stage pleural patients in stages 1-3 are the most common candidates for surgery. Some stage 4 patients are getting surgery as part of clinical trials.

Peritoneal mesothelioma patients have an even better outlook. It’s no longer uncommon for peritoneal patients to live years past their diagnosis. Specialists like the retired Dr. Paul Sugarbaker pushed patients beyond 5 and sometimes 7 years of survival.

For patients who do not qualify for surgery, other treatment options can still help. Learn more about mesothelioma treatments in your Free Mesothelioma Veterans Packet.

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Mesothelioma Surgery Eligibility

Before surgery, your doctors need to know if you're in good overall health and whether you can recover. This involves doing certain tests that measure your heart and lung health.

Common tests to determine eligibility for surgery include:

  • Electrocardiogram (EKG)
  • Cardiac stress test
  • Pulmonary function tests
  • Echocardiogram
  • Angiogram

If these tests results are normal, your doctor will consider doing surgery to help treat the mesothelioma.

Types of Mesothelioma Surgeries

There are 3 broad types of mesothelioma surgery:

  1. Diagnostic - How cancer is discovered and diagnosed
  2. Curative - How cancer is treated successfully
  3. Palliative - Focused on relieving patient discomfort

Diagnostic Mesothelioma Surgeries

Diagnostic surgeries help get biopsies of diseased tissue. Sometimes these surgeries are noninvasive. They only involve small incisions and placing a small camera to find tumors. Doctors remove a tissue sample through a tiny incision.

Other diagnostic surgeries are more invasive, full surgical procedures. Surgeons operate to get a better look at the extent of the disease.

Some surgeries used to diagnose mesothelioma include:

  • Core biopsy
  • Fine needle biopsy
  • Excisional biopsy
  • Laparoscopy
  • Mediastinoscopy
  • Open lung biopsy
  • Thoracoscopy
  • Additional types of biopsies

The type of diagnostic surgery performed depends on the type of mesothelioma. It also depends on the skill and preference of the mesothelioma specialist.

Curative Mesothelioma Surgeries

Surgery can be done before or after chemotherapy and radiation therapy. Chemotherapy before surgery is called neoadjuvant therapy, and after it is called adjuvant therapy.

Did you know

If a patient has less advanced mesothelioma, surgery may be performed with curative intent. The term "curative" is more of an expression in the medical field.

With the treatment of any cancer, remission is the primary goal. Remission means there are no signs of cancer on test results, but doctors agree the cancer can come back. This is why some doctors don't use the word "cure."

All the same, "curative surgery" is a common phrase used to describe the following treatments.

In curative surgeries, doctors remove all visible signs of mesothelioma tumors. Other organs and tissue may also be removed.

  • Extrapleural Pneumonectomy (EPP)

    In this radical thoracic surgery, the entire affected lung is removed. Parts of the lining of the lung (pleura) and diaphragm are also removed. This is an invasive surgery that can be risky for some patients. It takes several weeks to recover from. Many people have lived long past their prognosis after receiving an EPP.

  • Pleurectomy With Decortication (P/D)

    In this surgery, the cancer is removed along with the pleural lining. The surgeon doesn't remove the lung or diaphragm. This procedure is less invasive than the EPP. People who have this surgery tend to live up to 19 months after having it performed. Some live even longer.

  • Cytoreduction With HIPEC

    This procedure is performed on patients with peritoneal mesothelioma. First, doctors remove all visible tumors through cytoreductive surgery. Then, they put heated chemotherapy (hyperthermic intraperitoneal chemotherapy) inside the abdominal cavity, which helps kill off any remaining cancer cells. Some people who have had this type of surgery have lived 5 years or more.

Thoracic surgeon Dr. Robert Cameron, who developed the lung-sparing P/D operation, treats veterans enrolled in health care programs through the U.S. Department of Veterans Affairs (VA). As one of the most respected mesothelioma surgeons in the world, Dr. Cameron treats mesothelioma patients at the West Los Angeles VA Medical Center.

Veterans who have been diagnosed with mesothelioma may qualify for benefits through the VA. Request our free Veterans Packet to learn more.

Palliative Mesothelioma Surgeries

Sometimes surgery is done just to relieve mesothelioma symptoms. To cure the disease or extend the individual’s lifespan is not the goal of palliative surgery. The goal is to make patients comfortable. Palliative surgery is an option at any stage of mesothelioma.

Types of palliative surgery include the following:

  • Pleurodesis: This procedure is for patients with pleural mesothelioma. It involves inserting a flexible tube into the chest cavity so that fluid (pleural effusion) can drain from around the lung. Then drugs are administered into the chest cavity in order to prevent the further build up of fluid. The chemotherapy drug called bleomycin is sometimes used as part of the pleurodesis procedure.
  • Thoracotomy: This is an incision in the chest wall. These procedures allow doctors to go inside the chest to remove large tumors and drain fluid. It helps reduce a patient's pain and makes it easier to breathe.
  • Paracentesis: This surgery is for patients with peritoneal mesothelioma. Like pleurodesis, a hollow tube is inserted into the patient. Doctors remove fluid from the abdomen so patients can feel less pressure and less shortness of breath.
  • Segmentectomy: This is also called a wedge resection.  Doctors remove cancer in one area of the lung, leaving the rest of the lung intact. It is less invasive to do this type of surgery than removing the entire lung. Segmentectomy does not remove all the cancer. Shortness of breath and chest pain may be relieved after this procedure.
  • Lobectomy: One or more of the lobes of the lung are removed. It is used when the cancer appears in just one lobe of the lung. It is less invasive than removing the entire lung. A lobectomy can relieve symptoms.
  • Shunt or catheter placement: Doctors put a tube in the pleural or peritoneal cavity so that fluid can continually drain from the area. This eliminates the need to do repeat surgeries to remove the buildup of fluid.

The type of mesothelioma surgery depends on the stage and cell type you have. It also depends on the preferences of your mesothelioma specialist. Each specialist has his or her own area of expertise and may prefer one type of surgery over another.

Pleural Mesothelioma Surgery Debate

There is an ongoing debate regarding the most effective curative surgery to treat pleural mesothelioma.

Is the radical EPP more effective? Some doctors argue that it can remove more of a patient’s cancer. Is the lung-sparing P/D more effective? Doctors who favor P/D say that patients live longer if they keep both lungs.

Let’s examine the arguments and review what some doctors are saying.

Extrapleural Pneumonectomy

This surgery has extended the lives of countless patients. The late Dr. David Sugarbaker designed the modern EPP and extended patients' lives by years with the addition of chemotherapy.

The theory behind the EPP is to remove as much of the mesothelioma as possible. But some doctors don’t agree that this is possible. They argue that the chest is too complex to get a full resection of tumors.

There are only thin linings between the chest wall and lungs, which are not easy areas to operate in. P/D supporters think it’s better to remove what you can see and use chemo or radiation to treat what’s left.

If you are looking for a doctor to treat your diagnosis, use our Doctor Match today to find a specialist near you.

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Pleurectomy With Decortication

Dr. Robert Cameron is a staunch supporter of P/D. Like the EPP, P/D became effective once doctors learned the right combinations of other drugs to use with the surgery. Dr. Cameron even uses novel medications to treat his surgical patients.

Doctors in the P/D camp don’t just say it’s possible to remove most of the cancer with P/D. They argue that EPP doctors are trying too hard.

“Taking out a lung does harm and there is absolutely no benefit to the patient.”
—Dr. Robert Cameron

Visit the UCLA Health website to learn more about Dr. Robert Cameron.


The Mesothelioma Veterans Center has no affiliation with and is not endorsed or sponsored by Dr. Robert B. Cameron. The contact information above is listed for informational purposes only. You have the right to contact Dr. Cameron directly.

EPP vs. P/D for Mesothelioma

Some doctors are dedicated to one surgery over the other, but many more are dedicated to studying the benefits of both.

Dr. Raja Flores has argued that there is a place for the EPP and the P/D. According to him, the right surgery depends on the specific patient. Older patients may benefit more from both lungs. Late-stage patients may benefit more from EPP.

But every diagnosis is different, and there are many factors to consider. There are some new approaches to the EPP where stage 3 and 4 patients live for more than 3 years.

Yet the same has been true of novel approaches to P/D. There is a middle ground to these treatments that depend on each unique diagnosis.

Did you know?

Surgery is becoming a reality for more late-stage mesothelioma patients.

Once patients reach stage 3 mesothelioma, their disease often becomes inoperable. But new treatment approaches are giving late-stage patients a chance.

One treatment doctors are researching is P/D with photodynamic therapy. Photodynamic therapy uses a powerful type of light to kill mesothelioma cells during surgery. In one study, stage 3 and 4 patients who had this procedure had a median survival time of 3 years.

Mesothelioma doctors don’t prescribe surgery on its own. Surgical candidates also get chemotherapy or radiation to make surgery more effective.

“Patients with favorable prognostic factors can experience extended survival by undergoing trimodality therapy with extrapleural pneumonectomy, chemotherapy, and/or radiation,” said the authors of a 2010 report. One of the authors of this report is the late renowned mesothelioma specialist, Dr. David Sugarbaker.

Is Mesothelioma Surgery Right for You?

Potentially curative surgeries are your best bet if your disease isn’t advanced, though patients with advanced or metastasized mesothelioma have options too. Your doctor will help you minimize your pain and discomfort.

And though it’s less common, some stage 4 patients have gotten life-extending surgery in clinical trials.

Key points on mesothelioma surgery:

  • There are surgical options for all patients regardless of their diagnosis.
  • Surgery can relieve painful symptoms.
  • Surgery has led many patients to longer, happier lives.

There are cancer centers across the country where you can get surgical treatment. Even VA health care facilities in Los Angeles and Boston have mesothelioma specialists on board.

Find out more by talking to a VA specialist now.

Veterans Support Team
Todd Gersten, MD PhotoReviewed by:Todd Gersten, MD

Double Board-Certified Oncologist and Hematologist

  • Fact-Checked
  • Editor

Todd Gersten, MD, is a double board-certified medical oncologist and hematologist specializing in general adult oncology and hematologic disease. He is a physician partner with the Florida Cancer Specialists and practices in Wellington, Florida.

Dr. Todd Gersten is an independently paid medical reviewer.

Christopher Dryfoos PhotoWritten by:

Contributing Author

Christopher Dryfoos is a journalist and member of the American Medical Writers Association (AMWA). As the grandson of the U.S. Navy’s first forensic pathologist, he aims to help veterans with mesothelioma access needed care.

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  2. Cancer Research UK. “Surgery for Peritoneal Mesothelioma.” Retrieved from: Accessed on April 2, 2024.
  3. Cancer Research UK. “Surgery for pleural mesothelioma.” Retrieved from: Accessed on April 2, 2024.
  4. Cho, B. C., Feld, R., Leighl, N., et al. (2014). A feasibility study evaluating Surgery for Mesothelioma After Radiation Therapy: the "SMART" approach for resectable malignant pleural mesothelioma. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 9(3), 397–402. Retrieved April 2, 2024, from
  5. Flores, R. M., Pass, H. I., Seshan, V. E., et al. (2008). Extrapleural pneumonectomy versus pleurectomy/decortication in the surgical management of malignant pleural mesothelioma: results in 663 patients. The Journal of thoracic and cardiovascular surgery, 135(3), 620–626.e6263. Retrieved April 2, 2024, from
  6. Nikbakhsh, N., Pourhasan Amiri, A., & Hoseinzadeh, D. (2011). Bleomycin in the treatment of 50 cases with malignant pleural effusion. Caspian journal of internal medicine, 2(3), 274–278.
  7. Papaspyros, S., & Papaspyros, S. Surgical Management of Malignant Pleural Mesothelioma: Impact of Surgery on Survival and Quality of Life—Relation to Chemotherapy, Radiotherapy, and Alternative Therapies", International Scholarly Research Notices, 2014, Article ID 817203. Retrieved April 2, 2024, from
  8. Sugarbaker, D. J., & Wolf, A. S. (2010). Surgery for malignant pleural mesothelioma. Expert review of respiratory medicine, 4(3), 363–372. Retrieved April 2, 2024, from