COVID-19 Update: Our team is ready to serve you. Get Your Free Veterans Packet

Mesothelioma Diagnosis

Quick Summary

Doctors use a variety of tools to make a mesothelioma diagnosis. They will examine your symptoms, then perform imaging tests (X-ray, MRI, CT) and biopsies (needle, tissue/surgical) to diagnose mesothelioma. Getting an accurate diagnosis is critical to getting the best treatment.

Get a FREE Veterans Packet

Steps to Diagnosing Mesothelioma

A mesothelioma diagnosis starts with your symptoms. Most patients see their general practitioner after a couple of months with symptoms. At first, your doctor may suspect a common condition like pneumonia or irritable bowel syndrome. This leads to imaging tests.

Common symptoms of pleural mesothelioma include:

  • Chest pain
  • Cough
  • Difficulty breathing
  • Fatigue
  • Pain in the upper back
  • Rib pain
  • Shortness of breath
  • Shoulder pain
  • Trouble swallowing

Common symptoms of peritoneal mesothelioma include:

  • Abdominal pain
  • Abdominal swelling
  • Constipation
  • Nausea
  • Vomiting
  • Blood in vomit and/or feces
  • Weight loss

Doctors use imaging tests to locate the source of symptoms, such as tumors located in the chest and abdomen. You may be required to see a pulmonary (lung) specialist or oncologist. Pulmonary specialists and oncologists have more experience examining symptoms and imaging tests, especially when cancer is suspected. Your pulmonary specialist may ask you about your work and military service history.

Did you know?

Veterans have an increased risk of getting mesothelioma due to asbestos exposure in the military. Veterans who worked in shipbuilding, naval shipyards or construction have the highest rates of asbestos exposure. With a detailed exposure history, doctors are more likely to go straight to specific tests for mesothelioma.

Your history of asbestos exposure can be crucial in helping doctors make a mesothelioma diagnosis. This history includes a description of what kind of work you did during and after the military. It is very rare to be diagnosed with mesothelioma in a single visit. Expect several visits and multiple tests in order to make the diagnosis.

When you get the appointment with the specialist, prepare to spend up to an hour at the first consultation. Your doctor will help you pinpoint your history of asbestos exposure. Try to remember any exposures you may have had with lung-cancer inducing substances, including asbestos.

“A suspicion of mesothelioma should always arise when a patient with a case history of reasonable asbestos exposure is examined for pleural effusion or pleural masses of unknown [origin],” according to an editorial in the European Respiratory Journal.

Eventually, your doctor will confirm your mesothelioma diagnosis. You should be referred to a mesothelioma specialist at this time if you haven’t already. Your specialist may run other tests to get a more accurate picture of your diagnosis.

Further testing helps them create a tailored treatment plan based on your specific situation. This type of specialized treatment isn’t possible without a mesothelioma specialist. Specialists may also be a part of clinical trials testing new ways of treating mesothelioma.

Difficulties with Making a Mesothelioma Diagnosis

Mesothelioma can be difficult to diagnose. Most people don’t get diagnosed until 2-3 months after the onset of their symptoms.

Several things can get in the way of a proper mesothelioma diagnosis, including:  

  • Nonspecific symptoms: Mesothelioma symptoms are similar to those of many other diseases. Many conditions cause weight loss, coughing, fatigue and chest pain. Mesothelioma is so rare that it is not the first thing doctors think of unless they know you have a history of asbestos exposure.
  • Difficulty seeing on X-ray: Small areas of mesothelioma just look like thickening of the pleura (the lining of the lungs), and it might not be visible at all on an X-ray. Many patients need a CT or MRI scan of the chest to see the areas of cancer.
  • Difficulty getting an accurate biopsy: Tissue samples can look like other types of cancer under the microscope. The wrong diagnosis on a pathology report can lead to treatment that is ineffective for mesothelioma.

Imaging Studies for Mesothelioma

  • An X-ray is often the first scan doctors perform when making a mesothelioma diagnosis. It can show a fluid buildup in the lungs or abdomen and thickening in the lining of the lungs. X-rays are most helpful when doctors need to make a pleural mesothelioma diagnosis.
  • Computed tomography (CT) scans may be ordered of the chest, abdomen or both. CT scans take longer than X-rays, but they have more detailed images. CT scans use X-ray energy and a computer to create cross-sectional pictures of the organs inside the body. Doctors can see the size and location of tumors more easily with these scans. This test is helpful for locating peritoneal tumors.
  • Magnetic resonance imaging (MRI) is useful when determining how far mesothelioma has spread, including to nearby lymph nodes and organs. A doctor may take MRI scans of the chest, abdomen or both. Like the CT scan, it creates cross-sectional pictures of the organs inside the body. MRI scans use strong magnets and radio waves to see bones, soft tissue, and organs in the chest and abdomen.
  • Positron emission tomography (PET) scans use radioactive protein to identify potentially cancerous cells within the body. Before a PET scan, patients are injected with radio-labeled glucose that is absorbed by cancer cells more than other cell types. The PET scan then finds the cells that absorbed the sugar.
  • While CT-PET scan combination scans are considered the best way to confirm a mesothelioma diagnosis, your cancer may be found using any of the other types of imaging tests.  

Getting a Biopsy

A biopsy is a tissue or fluid sample taken from a potentially cancerous area found on an imaging test. It may take up to two weeks to get scheduled for a biopsy. It can take up to two more weeks to get a mesothelioma diagnosis after a biopsy has been taken. There are several ways doctors take a biopsy.

These are some ways doctors obtain biopsies:

  • Fine needle aspiration: A thin, hollow needle is inserted through your skin, guided by imaging techniques. Fluid and/or tissue can be drawn up through a syringe.
  • Thoracoscopy: A camera is attached to the end of a tube and is inserted into the lung cavity.  The cancerous areas can be seen with the camera and the biopsy is taken using small tools attached to the thoracoscope.
  • Mediastinoscopy: This test is similar to a thoracoscopy. The tube is inserted near the neck. There is a camera that can show areas that look cancerous. These cancerous areas can be sampled and looked at under the microscope.
  • Laparoscopy: This is a test to look for peritoneal mesothelioma. A camera attached to the end of a tube is inserted into the suspected part of the abdomen. Areas that look cancerous are sampled using small tools associated with the laparoscope.
  • Incisional biopsy: This is also called a core biopsy. Doctors take a larger sample of the cancer but do not remove the entire cancer.
  • Excisional biopsy: In this type of biopsy, an attempt is made to remove all visible signs of cancer in the hope of curing the cancer. This is not always possible when diagnosing mesothelioma, which has often spread by the time of diagnosis.

Pathology Tests

After your doctor has obtained a biopsy, the next step is to test it. The tissue sample needs to be reviewed under the microscope by an expert pathologist.

Pathologists examine the cells found in your biopsy. They are able to determine if there are mutations among the healthy cells, which is how cancer is found. Then the pathologist notes the characteristics of the cancerous cells.

Mesothelioma cells have specific traits that can be revealed by immunohistochemistry, which selectively exposes special antibodies only found on mesothelioma cells.

The pathologist might have trouble diagnosing mesothelioma because it can look like other kinds of cancer. More biopsies or further testing may be necessary to make an official mesothelioma diagnosis.

Did you know?

Adenocarcinoma and mesothelioma have similar cellular structures. Electron microscopy can help doctors distinguish mesothelioma cells from adenocarcinoma. This type of imaging uses an electron microscope to get a much higher magnification of a biopsy or fluid sample.

Blood Tests for Mesothelioma

Because of recent research, blood tests called biomarker tests have been found effective in some mesothelioma patients. Doctors are developing blood tests that may one day lead to earlier diagnoses.

Did you know?

There is a Food and Drug Administration (FDA) approved test called MESOMARK, which tests for proteins found on mesothelioma cells. The proteins are called soluble mesothelin-related peptides (SMRPs). People with mesothelioma often have elevated levels of SMRPs in their blood.

Another biomarker tests for the presence of a protein known as osteopontin. There are elevated levels of this protein in some mesothelioma patients, though osteopontin levels also rise with other conditions. Researchers are still testing how reliable osteopontin is to diagnose mesothelioma.

Blood tests can help confirm a mesothelioma diagnosis, but scans and biopsies still need to be done to determine if the cancer is present.

Next Steps after a Mesothelioma Diagnosis

To make a mesothelioma diagnosis, a team of specialists is needed. Some doctors are better at conducting imaging tests, while others are trained to accurately interpret mesothelioma biopsies. Some pathologists are trained to distinguish the difference between mesothelioma and other types of cancer. A team of specialists like this can help ensure you get the most specific treatment for your disease.

Things to remember about your mesothelioma diagnosis:

  • Sometimes mesothelioma is confused with other types of cancer.
  • Biopsy samples are the only conclusive way to diagnose mesothelioma.
  • If you haven’t yet, talk to your doctor about a second opinion.

Now that you have a diagnosis, you need to decide if you’re ready to accept it. Every mesothelioma patient should consider a second opinion about their mesothelioma diagnosis. You can be more certain about your treatment when two or more specialists agree on your treatment. A second opinion may even reveal new treatment options that prolong your survival time. Find out more about getting a second opinion now.

Veterans Support Team
Todd Gersten, MD PhotoReviewed by:Todd Gersten, MD

Double Board-Certified Oncologist and Hematologist

  • Fact-Checked
  • Editor

Todd Gersten, MD is a double board-certified medical oncologist and hematologist specializing in general adult oncology and hematologic disease. He is a physician partner with the Florida Cancer Specialists and practices in Wellington, Florida.

Dr. Todd Gersten is an independently paid medical reviewer.

Christopher Dryfoos PhotoWritten by:

Contributing Author

Christopher Dryfoos is a journalist and member of the American Medical Writers Association (AMWA). As the grandson of the U.S. Navy’s first forensic pathologist, he aims to help veterans with mesothelioma access needed care.

View Sources

American Cancer Society. “Can Malignant Mesothelioma Be Found Early?” Retrieved from: Accessed on August 28th, 2017.

American Cancer Society. “How is Malignant Mesothelioma Diagnosed?” Retrieved from: Accessed on August 28th, 2017.

G. Martensson. European Respiratory Journal. “Diagnosing malignant Pleural Mesothelioma.” 1990. Retrieved from: Accessed on August 28th, 2017.

Back to Top