Pleural Mesothelioma

Quick Summary

The most common kind of mesothelioma in veterans is pleural mesothelioma. This disease causes tumors to develop in the lining of the lung and chest cavity. Common treatments for pleural mesothelioma include radiation, chemotherapy, and surgery. Patients can live years beyond their prognosis by combining these treatments.

What is Pleural Mesothelioma?

Pleural mesothelioma is the most common type of mesothelioma. It’s caused by inhaling asbestos fibers. Many veterans were exposed to asbestos in the military and in their occupations following their service.

When someone inhales asbestos dust, the tiny needle-like fibers get trapped in the lining of the lungs, known as the pleura. These fibers are difficult or impossible to cough up. Over time, the needles migrate farther into the pleura, remaining lodged up to 60 years in some cases.

Did you know?

Over time, the fibers irritate the pleura and scar tissue begins to build. The scar tissue grows in the lining of the lungs, creating tumors. Parts of these tumors may break off and spread through the bloodstream and lymph system. This is how pleural mesothelioma spreads throughout the body.

The median survival for pleural mesothelioma patients is 12-21 months. Survival time depends on factors such as age and disease stage at the time of diagnosis. It’s important to remember that these statistics aren’t based on patients who are currently living with the disease.

Many people have survived long beyond the median survival times.

Facts About Pleural Mesothelioma

  • It is caused by the inhalation of asbestos fibers
  • It occurs commonly in veterans exposed to asbestos in military construction and naval shipyards
  • It is the most common type of mesothelioma
  • Family members of asbestos workers can get mesothelioma too
  • Changes in the pleura of the lung don’t occur for at least 10 years
  • Calcium deposits are the first sign that asbestos has infiltrated the pleural membrane
  • Pleural plaques (inflamed tissue) put you at a higher risk of having mesothelioma later in life
  • It is aggressive, often metastasizing within one year after diagnosis

Symptoms of Pleural Mesothelioma

Common symptoms include:

  • Chest pain
  • Chronic shortness of breath
  • Lumps on the skin of the chest wall
  • Persistent cough
  • Unexplained weight loss

Pleural mesothelioma symptoms are nonspecific. Several conditions have the same symptoms as mesothelioma. Patients may think they just have a chest infection or pneumonia. If your symptoms do not go away after several weeks of coughing and chest pain, or if you notice lumps beneath the skin of the chest area, you may need to get tested for mesothelioma.

Mesothelioma is very rare. Many doctors may only see one or two cases over their careers and may not be familiar with the symptoms. Make sure to tell your doctor about your asbestos exposure history and discuss mesothelioma testing.

Diagnosing Pleural Mesothelioma

An X-ray, CT scan or MRI scan of the chest can show thickening of the lining of the lungs. This can be an indication that you have asbestos plaques on your pleural tissue. Some of these plaques may be cancerous. To get a proper diagnosis, you need to get a biopsy from the affected area. A biopsy is a tissue sample used to test for cancer. It’s the only conclusive way to diagnose pleural mesothelioma.

If the Diagnosis of Mesothelioma is Positive

If you are diagnosed with pleural mesothelioma, you’ll want to see one of the top doctors who treat mesothelioma.

Some of the best Mesothelioma Specialists in the country are at VA medical centers in:

Some top pleural mesothelioma doctors to contact include:


The Mesothelioma Veterans Center has no affiliation with and is not endorsed or sponsored by Dr. Robert B. Cameron. The contact information above is listed for informational purposes only. You have the right to contact Dr. Cameron directly.

Get a FREE Veterans Packet

Get information on:

  • Treatment Options
  • Mesothelioma Specialists
  • Veterans Benefits

Learn More

Stages of Pleural Mesothelioma

Pleural mesothelioma has 4 stages. These stages are either early or advanced. They help explain how far the mesothelioma has spread in the body. There are more treatments available for patients with early-stage disease. However, the disease stage alone isn’t the only factor when doctors prescribe treatment. Late-stage patients often qualify for radical treatments that can prolong their lives.

Here is a simple description of each stage of pleural mesothelioma:

Stage 1 Tumors are confined to the lining of one lung.

Stage 2Tumors have spread to other parts of the lung or diaphragm.

Stage 3 Lymph nodes and other organs contain signs of cancer.

Stage 4 Cancer has finally spread to the other side of the chest.

Treating Pleural Mesothelioma

Treating pleural mesothelioma requires more than one treatment method. The most successful patients receive a combination of surgery, chemotherapy, radiation and experimental therapy if possible. This kind of treatment requires not only a mesothelioma specialist but a team of specialists.

A report published by the National Center for Biotechnology Information (NCBI) regarding the treatment of mesothelioma stresses the importance of picking the right cancer center:

“The growing complexity of treatment protocols mandates that [mesothelioma] patients be referred to specialized centers,” said the authors. They continue saying that “every component of the interdisciplinary team can provide the necessary expertise and quality of care.”


Surgery is the best treatment to extend your life. Patients with early-stage mesothelioma are usually eligible for surgery. Late-stage patients may also be eligible depending on the opinion of the surgeon. In some cases, the benefits of surgery may not apply to late-stage patients. This is because pleural mesothelioma often metastasizes (spreads) to other body areas in later stages. Common areas of metastasis are the lymph nodes, diaphragm, and abdominal organs.

If your mesothelioma specialist thinks that surgery will work for you, there are two major surgeries they may consider.

Surgeries for pleural mesothelioma include:

  • Extrapleural pneumonectomy (EPP): Patients with localized disease may be eligible for the extrapleural pneumonectomy (EPP). This a radical surgery that removes the entire affected lung. During an EPP, parts of the pericardium, the diaphragm, and the pleural tissue are removed along with the cancerous lung.
  • Pleurectomy with decortication (P/D): During this procedure, doctors carefully remove tumors along with any other areas of the affected lung. Some Mesothelioma Specialists prefer this surgery because it is less radical of a procedure than the EPP.

The type of surgery that is right for you depends on your unique situation. Many doctors will start with a P/D in mind. However, if the affected lung is overrun with pleural plaques, an EPP may provide a better chance at removing all of the tumor masses.


Chemotherapy is the most common treatment for mesothelioma. It’s used at all stages of pleural mesothelioma, often combined with surgery or radiation.

Chemotherapy is often the best option if the mesothelioma has already spread to other tissues at the time of diagnosis.

There have been many types of chemotherapy used in clinical studies. Currently, only a combination of Alimta (pemetrexed) and cisplatin are approved by the U.S. Food and Drug Administration. Going through chemotherapy can be difficult but the process has shown to shrink tumors caused by mesothelioma.

Did you know?

A study published in May 2017 showed that pleural mesothelioma patients who received a combination of treatments lived longer. The patients who had chemotherapy, surgery and postoperative radiation had a median survival of 35.6 months. Most patients were in stage 3 of their disease, effectively doubling their survival time.

Radiation Therapy

Radiation therapy is used to treat some cases of pleural mesothelioma. It is often combined with other treatments, like chemotherapy or surgery. Radiation uses painless X-ray waves that destroy parts of the tumor. Radiation can shrink the tumors but is not considered a curative measure on its own. Oftentimes, doctors prescribe radiation before surgery. Shrinking the tumors first may make surgery more successful.

Alternative Therapy

Alternative therapies have become popular in the treatment of mesothelioma pain and symptoms. These therapies include reflexology, acupuncture, or massage. Most of these treatments help mesothelioma patients feel better and less anxious. Patients using alternative therapies may tolerate the stress of having chemotherapy and radiation better than patients who do not.

It’s important to speak with your doctor first before trying alternative therapy. According to the American Cancer Association, “Although some of these methods might be helpful in relieving symptoms or helping you feel better, many have not been proven to work. Some might even be dangerous.”


Your doctor has probably given you a mesothelioma prognosis based on the stage of your disease. A prognosis is the likely outcome of your disease, or how fast it will progress. It’s also discussed in terms of survival time.

According to the American Cancer Association, the median survival times for pleural mesothelioma are:

Stage 1 – 21 months

Stage 2 – 19 months

Stage 3 – 16 months

Stage 4 – 12 months

Remember that every patient is different. Survival times are more dependent on the treatments you receive. Furthermore, survival times vary drastically on an individual basis. Some pleural mesothelioma patients have lived years and years with the disease.

FREE Veterans Guide

Secure Submission

Taking Control of Your Prognosis

Research for pleural mesothelioma is advancing rapidly for such a rare disease. There are many experimental treatments currently showing promise. Some of these include gene therapy and immunotherapy, which alter a patient’s genetics or immune system to fight mesothelioma. These treatments are in clinical stages. It goes to show that no matter your diagnosis, there are options available for every patient.

Points to remember:

  • Pleural mesothelioma patients are living longer than ever
  • New treatments are worth discussing with your doctor
  • You can outlive your prognosis

You can Learn More about your treatment and support options in our free Mesothelioma Veterans Packet.

Veterans Support Team
Christopher DryfoosWritten by:

Contributing Author

Christopher Dryfoos works hard to help veterans with mesothelioma learn how to access the care they need. Using his experiences as a journalist and Boy Scout, he strives to keep our content trustworthy, helpful, and easy to read.

View Sources

Treating Malignant Mesothelioma. American Cancer Association. Retrieved from: Accessed: August 18, 2017.

Survival Statistics. American Cancer Association. Retrieved from: Accessed: August 18, 2017.

Mesothelioma Symptoms. Mayo Clinic. Retrieved from: Accessed: August 18, 2017.

Diagnosing and Treating Mesothelioma. American Lung Association. Retrieved from: Accessed: August 18, 2017.

Casiraghi, Monica. “Induction chemotherapy, extrapleural pneumonectomy and adjuvant radiotherapy for malignant Pleural Mesothelioma.” 2017.

Retrieved from: Accessed: August 18, 2017.

Marulli, Giuseppe. “Induction chemotherapy vs post-operative adjuvant therapy for malignant Pleural Mesothelioma.” Retrieved from: Accessed September 8th, 2017.

Back to Top